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KMID : 1123920020160010146
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.146 ~ p.149
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Effect of Ziziphi Jujubae Semen on 5-Fluorouracil Induced cytotoxicity in Cultured Vestibular Neurons
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Son Il-Hong
Lee Jung-Hun
Choi Yu-Sun
Lee Jae-Kyoo
Kim Hyung-Soo
Lee Yong-Suk
Lee Whan-Bong
Choi Ki-Wook
Min Bu-Ki
Kim Sang-Su
Lee Kang-Chang
Ryu Myeung-Hwan
Song Ho-Jun
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Abstract
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To evaluate the protective effect of Ziziphi Jujubae Semen(ZJS) on 5-Fluorouracil(5-Fu) in cultured vestibular neurons(VN), neurotoxicity was assessed by XTT assay after VN was exposed to 3-24ug/ml 5-Fu for 48 hours. and also, the neuroprotective effect of ZJS was measured by XTT assay in these cultrures. Cell viability was remarkably decreased dose-dependently, after the treatment with 12ug/ml 5-Fu to cultured VN for 48 hours. In the neuroprotective effect of ZJS on the toxicity induced by 5-Fu, ZJS prevented the neurotoxicity induced by 5-Fu in these cultures. From above the results, it suggests that 5-Fu is toxic in cultured VN and herb extract, ZJS has protective effect over the neurotoxicity induced by 5-Fu.
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KEYWORD
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Ziziphi Jujubae Semen (ZJS), vestibular neuron, Neurotoxicity
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